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joingrace
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¾Æ·¡´Â Ƽ¸Þ·Î»ì°ú ¼öÀºÀÌ ÀÚÆóÁõÀ̳ª ¾î¸°¾ÆÀÌÀÇ ½Å°æ¹ß´Þ¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» °üÂûÇÑ ³í¹®ÀÔ´Ï´Ù.

Neuro Endocrinol Lett. 2005 Oct 30;26(5) [Epub ahead of print] Related Articles, Links  


Mercury and autism: Accelerating Evidence?

Mutter J, Naumann J, Schneider R, Walach H, Haley B.

Institute for Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Germany. joachim.mutter@uniklinik-freiburg.de.

The causes of autism and neurodevelopmental disorders are unknown. Genetic and environmental risk factors seem to be involved. Because of an observed increase in autism in the last decades, which parallels cumulative mercury exposure, it was proposed that autism may be in part caused by mercury. We review the evidence for this proposal. Several epidemiological studies failed to find a correlation between mercury exposure through thimerosal, a preservative used in vaccines, and the risk of autism. Recently, it was found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Repetitive doses of thimerosal leads to neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequently, autistic children have significantly decreased level of reduced glutathione. Promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites.

°£´ÜÈ÷ ¿ä¾àÇÏÀÚ¸é....
¹Ýº¹ÀûÀÎ ¼öÀºÀ̳ª Ƽ¸Þ·Î»ìÀÇ Åõ¿©°¡ ÀÚÆó³ª ³ú½Å°æ ¹ß´ÞÀå¾Ö¸¦ ÃÊ·¡ÇÒ¼ö ÀÖ´Ù. ¾ÕÀ¸·Î ÀÚÆóÀÇ Ä¡·á¿¡ À־ ¼öÀºÁßµ¶ÀÇ ÇØ°áÀ̳ª ÀÌ·Î ÀÎÇØ ºÎÁ·Çϱ⠽¬¿î ¼ººÐÀ» °ø±ÞÇØÁִ°ÍÀÌ ÇÊ¿äÇÏ´Ù.

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¾Æ·¡´Â Ƽ¸Þ·Î»ìÀÌ ÇÔÀ¯µÈ µ¶°¨¹é½Å¿¡ ´ëÇÑ ¾Ë·¹¸£±â¿¡ °üÇÑ ³í¹®ÀÔ´Ï´Ù.
Ann Allergy Asthma Immunol. 2005 Jan;94(1):90-4. Related Articles, Links  


A generalized reaction to thimerosal from an influenza vaccine.

Lee-Wong M, Resnick D, Chong K.

Division of Clinical Immunology and Allergy, Department of Internal Medicine, Beth Israel Medical Center, New York, New York 10003, USA.

BACKGROUND: Thimerosal is a preservative commonly used in ophthalmic solutions, otic drops, and vaccines because of its bactericidal property. OBJECTIVE: To report a case of a generalized reaction to thimerosal in a patient who received an influenza vaccine. METHODS: We describe a patient who developed a generalized maculopapular eruption after receiving a thimerosal-containing influenza vaccine. Patch testing was performed to determine if there was an allergy to thimerosal. RESULTS: Patch testing confirmed a T-cell-mediated sensitivity to thimerosal. CONCLUSIONS: Physicians need to be aware that thimerosal is found in many products, including vaccinations. Clinicians should also be aware that allergic reactions occur with exposure to thimerosal even in vaccines. To our knowledge, this is the first case report in the literature of a generalized reaction to thimerosalfrom an influenza vaccine.

Ƽ¸Þ·Î»ìÀº ¾È°úÁúȯ¿¡ ¾²ÀÌ´Â ¾È¾àÀ̳ª ¹é½Åµî¿¡ ÇÔÀ¯µÇ´Â Ç×±ÕÁ¦Àε¥, µ¶°¨¹é½Å¿¡ ÇÔÀ¯µÈ Ƽ¸Þ·Î»ìÀÌ ³ªÅ¸³»´Â ÀϹÝÀûÀÎ ¹ÝÀÀÀ» °üÂûÇÏ¿´´Ù. °á°úÀûÀ¸·Î ³»°úÀÇ»çµéÀº ¹é½ÅÁßÀÇ Æ¼¸Þ·Î»ìÀÌ ¾Ë·¯Áö ¹ÝÀÀÀ» ÀÏÀ¸Å³¼ö Àִٴ°ÍÀ» ¾Ë°í °æ°èÇØ¾ß ÇÑ´Ù.  

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¾Æ·¡´Â ¾ÆÅäÇÇȯÀڵ鿡°Ô À־ Ƽ¸Þ·Î»ì¿¡ ´ëÇÑ °ú¹Î¹ÝÀÀ¿¡ °üÇÑ ³í¹®ÀÔ´Ï´Ù.

Contact Dermatitis. 1999 Feb;40(2):94-7. Related Articles, Links  


Sensitization to thimerosal in atopic children.

Patrizi A, Rizzoli L, Vincenzi C, Trevisi P, Tosti A.

Department of Clinical and Experimental Medicine, University of Bologna, Italy.

Thimerosal is an organic mercurial compound widely used as a preservative in vaccines, eyedrops, and contact lens cleaning and storage solutions. 5 infants, 2 female and 3 male, ranging in age from 7 to 28 months and affected by atopic dermatitis (AD) diagnosed according to the Hanifin and Rajka criteria, experienced an exacerbation of their clinical condition 2-10 days after mandatory vaccinations with vaccines containing thimerosal. Cutaneous lesions of nummular eczema appeared on the trunk, limbs and face. All patients were patch tested with serial dilutions of thimerosal in petrolatum. A positive patch test reaction to thimerosal 0.1% pet. was observed in all 5 children. 3 of them also showed a positive reaction at 0.01% and 0.05% pet. Despite their thimerosal-hypersensitivity, all children completed the entire series of mandatory vaccinations, care being taken to use different needles for injection and aspiration of the vaccine. The 2-year follow-up did not reveal other episodes of exacerbation of the AD after vaccination. The present study confirms the high frequency of sensitization to thimerosal in atopic children and suggests that vaccination can cause clinical symptoms in sensitized children. Nevertheless, sensitization to thimerosal does not prevent children from continuing with mandatory vaccinations.

Ƽ¸Þ·Î»ìÀº ¹é½ÅÁßÀÇ ¹æºÎÁ¦·Î »ç¿ëµÇ´Âµ¥, ¾È¾à, ÄÜÅÃÆ® ·»Áî Ŭ·»Â¡ ¼Ö·ù¼Ç¿¡µµ ÇÔÀ¯µÈ´Ù. 5¸íÀÇ À¯¾Æ(7-28°³¿ù)µé¿¡°Ô Ƽ¸Þ·Î»ìÀÌ ÇÔÀ¯µÈ ¹é½ÅÀ» Á¢Á¾ÇÏ°í ³ª¼­ ÇǺκ¯È­¸¦ °üÂûÇÏ¿´´Ù. ¾ç¼ºÆÖÄ¡ Å×½ºÆ® »ó¿¡¼­ 5¸íÁß 3¸íÀÌ Æ¼¸Þ·Î»ì¿¡ ´ëÇؼ­ ¾ç¼ºÀûÀÎ ¾Ë·¹¸£±â °ú¹Î¹ÝÀÀÀÌ ³ªÅ¸³µ´Ù. °ú¹Î¹ÝÀÀÀÌ ÀÖÀ½¿¡µµ ¹é½ÅÁֻ縦 ÇÑÈÄ 2³âÈÄ °æ°ú¸¦ º¸¾Ò´õ´Ï ¾ÆÅäÇÇ»óÅÂÀÇ Å« º¯È­´Â ¾ø¾ú´Ù. À̹ø ½ÇÇèÀ» ÅëÇؼ­ ¾ÆÅäÇÇ ¾ÆÀ̵éÀÌ Æ¼¸Þ·Î»ì¿¡ ¿¹¹ÎÇÏ°Ô ¹ÝÀÀÇϴ°æ¿ì°¡ ¸¹´Ù´Â°Í°ú ¹é½ÅÁֻ簡 ¾ÆÅäÇÇ ¾ÆÀ̵鿡°Ô ÀÓ»óÀû Áõ»óÀ» ÃÊ·¡ÇѴٴ°ÍÀ» ¾Ë¼ö ÀÖ´Ù.







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